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Drink water

During recess, I sat at the classroom platform and looked at the students leisurely.. In fact, looking at them is like looking at the scenery. If the wind blows over the treetops, the leaves will vibrate and sing. If you look at the sun shining on the water, your eyes will be covered with a glimmer of thought and sparkling light in your heart..   Suddenly, I noticed that several students were drinking water at the drinking fountain. It may be that only one student in a group brought a cup today, so only one person can pick up a cup and then others can pick it up..   What I saw in particular was that there were men and women in this group, and each of them drank water in a’ chic’ way, lifting the cup as high as possible to the right place, lifting up the face, pursed up the mouth, and letting the cup mouth pour water at least three inches away from the lip.. Occasionally, water may overflow from the corners of the mouth or drip from the chin to the skirts of the clothes and onto the ground due to poor swallowing..   As if, this is not drinking water, but doing a kind of performance. However, I carefully look at these children, they are so natural, so completely casual and for. I am convinced that they are only drinking water in good faith and are not acting affectation at all..   This group of students is as beautiful as flowers and pure as the cleanest scenery. They are very good. I like them. Each of them has a sense of collectivity and fraternity. Even, I often see boys and girls holding each other’s hands and scribbling on the back of their hands and wrists during recess, which is so natural, so pure and so clear.. Think of our junior high school primary school drawing online on the desk, boys and girls at the same table will definitely not intentionally overstep it. ‘ Helpless flowers fall”,’ The deceased is like a husband.” Also.   There was no water dispenser in the classroom in that time. Some students who have ” enchanting” points have to drink water and go back to the classroom from home.. Most likely, he carried the bottle of water, most of which was always drunk by his classmates. Moreover, it must have been the appliance that took the water, that is, it was natural and natural to drink it by mouth.. Perhaps the lip prints are still in the mouth of the cup, but they do not prevent people from continuing to drink them..   Times are shaping people. Perhaps, to calculate, it is not difficult to know when we started to change the way we drink water..   It is said that Mr. Gu Hongming once refuted the criticism of polygamy. His example is that a man is like a teapot, a woman is like a teacup, and a teapot is often equipped with several teacups.. Mr koo is very interesting. if he lived to this day, he would be even more justified. Today, a teapot is usually not only equipped with a few cups, but often with a lot of disposable cups.. I don’t know what amazing language his old man’s house will utter, using these disposable cups words for example..   Suddenly, did I miss the time when I used cups instead of disposable cups to drink water?. When the guests arrive, the first one used the cup. Perhaps, the host only needs to rinse the cup symbolically at most and pour the cup onto the back end to the later ones.. Even, the cup is very big, the person in front is far from finished, and the person in the back may take it and drink it.. At that time, people often said that all tastes are the same. Now, people are paying attention to hygiene in their hearts.   I am a lazy person and never bother to spend any more time drinking water and drinking tea. If you are not thirsty, you will not drink; if you are thirsty, you will drink.. Because there is no habit of drinking tea, your breath is also brilliant. It has been almost 20 years since class began, and you never thought of bringing tea into the classroom.. However, occasionally, watching the students drink water, I really want to drink a jar of it, but for many years, I have been embarrassed to ask the students to drink water from their cups.. Because, I will be contradictory, do I just drink at the mouth or may I leave the lip marks on the mouth of the cup or just pout at the mouth to drink it? No matter what, it’s very troublesome. forget it, don’t drink it.   Most of the time, I was sitting in the office when a colleague came in: ah, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha, ha.   Well, yes.   There’s no cup.   Oh, no, there were a few left yesterday, all finished.   Colleagues had to look elsewhere for cups with a grudge.. In fact, my cup is at hand. I would like to say: Drink my cup. However, I can’t say. Because, perhaps, even if you have a medical certificate to show people, they still have feelings of sadness..   People, that may be the case. The more favorable the conditions, the more expensive they will be unconsciously. Isn’t it true that one day, when people are exposed to each other, they no longer express the support of adversity or the most reliable support, but when they think about it, they feel too unhygienic and want to vomit and vomit?.  Heard that, there are more exquisite families, the table has been used’ male chopsticks’.   Ha ha, just drink water, pull this off. With the development of human science and technology, the ego’s ability to resist viruses is definitely increasing. I don’t know if anyone has investigated it. I estimate that it should be weakening.. Because, judging from drinking water, people have more and more sealed themselves up.

Bird nest, crab, potato, leek

The village that gave birth to me and raised me will jump into my mind on a rainy autumn night like a rain flower between eaves..     There are always green and yellow thatched roads on the field roads, which are always tightly attached with glittering and translucent rain beads. The lush green curtains in the corn fields surround the whole mountain, and we live in the sea of corn stalks.. The village is not big and there are many people, but I can always find a place where no one can wander around..     Do you remember the big stone in the river beside Shanhou Primary School, which can hold three to five children to write on? After school, we came here carrying schoolbags, spread out the checkerboards and holding pencils to write. We lay there writing at ease, the sunset shining on our checkerboard, chasing our slow nib. Vaguely remember, there is sand adhered to our clothes.     After a long time of mixing, I like to explore around the river bank and drill through the bushes until I find a bird’s nest with a few small eggs in it.. We were excited, but we couldn’t bear to take them away, but since then we have formed the habit of drilling grass to find birds and eggs..     When he was a little older, he followed his brother and a younger brother to the river in the valley to make trouble.. Brother can climb up the big willow tree by the river very lightly, then pick out the slender leafy willow tree with a knife and throw it to us. We wound these wickers into a circle and formed willow hats, which we thought were very proud to wear on our heads..     Then he jumped into the river to fight for water, drenched with water and dried in the sun.. So summer began to cool down. Always remember to catch a few crabs under the stones to play and watch them stumble in the sand. A normal crab has a hard shell, while a drug crab’s shell is crushed by two fingers. We also ignored it and only caught normal crabs to play.     I also not only play, but also do some work for my mother. I like to pick up potatoes in the field with my mother best.. After the potatoes are harvested, they will leave some carelessly in the ground and will soon sprout seedlings again. We looked for seedlings in the field and pulled out a potato as soon as we pulled it out. Sometimes I can find the biggest one, and I’m as happy as I dug up the gold pieces..     Mother will cook the potatoes for me the next day. Big potatoes are peeled, cut into pieces, fried with oil, salted and steamed with rice, but they are delicious. My highest record was eating four white bowls at a time, and my father taught me a lesson, saying how to stay dead. All that is good is how many years I have eaten, but I still didn’t survive..     I also like to cut leeks in particular. Our leeks are planted under mulberry trees on the edge of the ground. They are thin due to lack of sunlight, but they are also fresh and tender.. The leek is a rare thing to pick up. It takes you half an hour to strip the yellow leaves and the old leaves one by one.. But I have to sit tight or I won’t be able to eat another delicious food.     In the evening, mother will make up flour, add leeks and make pancakes. The big iron pan in the house was well oiled, spread out into big pancakes, and then dried slowly. The leek leaves became finely divided jasper in the pancakes, and they had an appetite when they looked at them.. I have to eat two large sheets before I can sleep contentedly.     The village was finally submerged by deeper green, and those days suddenly occurred before they were gradually forgotten. I was always a child in that village, remembering the days when there were bird nests, crabs, potatoes and leeks..

A man is as old as a child

As old as a child, his father-in-law felt bad in his stomach and intestines and accompanied him to the 148 hospital of the garrison.. Find the director of the department and check carefully. Fortunately, there is no major obstacle, that is, gastrointestinal function is almost not serious. The doctor asked whether the medicine was still prescribed? I said, let’s open it up. The father-in-law also returned after prescribing more than 200 yuan of medicine. The next day, I called and said, OK.     Father – in – law’s stomach and intestines are not good, which has been an old problem for many years.. As the saying goes, stomach trouble is divided into three parts and seven parts. Fortunately, his life is very careful. He has paid attention to diet for decades. He did not eat cold and hard, but his stomach trouble has improved greatly in recent years.. But after the Spring Festival, he always felt dull pain in his abdomen. I can’t say exactly where the pain is. It’s just a feeling. I feel, like a heart disease again.     I think so, there is a basis. The father-in-law has a fine heart and a good temper. This is an advantage. Correspondingly, it is too sensitive.. Three years ago, when he was seventy, he always said his lips were dry. I accompanied him to the PLA hospital and looked for experts from acquaintances. I took them seriously.. Experts said there was nothing wrong with it. Drink plenty of water and eat and drink whenever you should.. Because he is an acquaintance, the doctor said very clearly: I will not prescribe any medicine for you, even if it is prescribed, it is also a nourishing medicine such as vitamins, and it will only cost money.. This should be very good, but he was even more suspicious: the doctor said that he should eat and drink if he should, and whether he had an incurable disease or not? I said, older, dry lips is a normal phenomenon. But he is still not at ease to look around. When I went to the provincial capital, my daughter-in-law’s mobile phone was stolen by thieves, but the daughter-in-law was reasonable and didn’t care about it.. He went to the city to watch the advertisement on TV. The Jianghu doctor prescribed only a few hundred yuan of medicine..     I didn’t feel normal at the time when he was so exciting and moving.. Ask your wife to call your mother – in – law. My mother-in-law said that when I was young, someone calculated the hexagrams for my father-in-law and said that he could live to be seventy years old. This year is just seventy years old. I always feel this afflictive and uncomfortable psychologically. I went there to see it..     Knowing the reason, we advised him that at that time, seventy was the birthday, and now living conditions are good and medical standards are high. At that time, seventy was at least over eighty, so you can rest assured.. So, finally better. Wait until you bring your grandson, and you forget to look at him.     In view of the last experience, I asked my mother-in-law again this time. It turned out that a colleague from the father-in-law unit had pancreatic cancer and could not come in three months from the Spring Festival.. Plus this year happened to be seventy – three, folk saying seventy-eight and eighty – four, Yan did not call himself to go. Under the psychological effect, father-in-law worried again.     I told the doctor about these factors. The doctor said he was relieved that the symptoms of pancreatic cancer came quickly, up to six months. Your color Doppler ultrasound showed that your pancreas is fine. The knot was untied, so I prescribed medicine and went back. I felt better the next day..     Compared with his father – in – law’s carefulness, his mother-in-law is generous and a little careless.. As for the old man’s illness, my opinion is that if he is ill, he should be treated and not too sensitive.. Her character is good for her health. A few years ago, I watched her lose weight and asked her to go to the hospital for examination. B ultrasound was performed in the local hospital and found a shadow on the abdomen, which was suspected to be a tumor at the time.. Father – in – law is extremely nervous, mother-in-law said, seven old eighty, love what is what. So careless don’t care. I came to the military hospital to find experts to examine it in detail. The experts confirmed that the abdomen was flooded and eliminated the tumor.. According to the water treatment for a period of time, he recovered and recovered.     Father, last year 73.The chronic cor pulmonale is especially serious. He has a stubborn temper and does not come to see a doctor. Always say that people are old, that’s all. See what. Rural medical insurance is basically not reliable. I know he is reluctant to spend money on his children. I went back to pick him up a few years ago and didn’t come. Daughter said, or call and say you are ill and let him come to see you, grandpa will certainly come. My daughter said that she was joking with me. I thought this girl must have watched more TV shows.. He couldn’t pick him up until a relative’s child got married and he had to come. After attending the wedding, I checked with him at the hospital, emphysema, chronic bronchitis, and bad heart. I prescribed medicine and took it for a long time, which improved slightly.. This winter is especially cold, and pulmonary heart disease is even more serious. I can’t breathe. I can’t sleep when it’s serious.. I went home to take a look at it and quickly picked it up. My friends in the hospital helped take care of it, contacted experts, gave injections and took medicine before getting better..     Mother used to pinch and scrape, usually loathe to give up eating, loathe to give up seeing a doctor. I always work at leisure and often get tired and ill. I came home and was ill twice before I came to see a doctor.. One time she went to the mountain to order beans. Mountain remote, would not have let her grow, loathe to give up desolate, just take advantage of the rain to grow beans. As a result, the old sick man who came back tired spent six or seven hundred yuan to see a doctor.. The beans also weighed 5kg. This truth has been told to her countless times and there is no way out. Later, she coaxed and advised that her granddaughter missed her and should go and have a look, and so on, she was finally brought in for treatment.. Fortunately, years of old illness have gradually improved, feeling better than in previous years, and children are really pleased. Therefore, when dealing with the elderly, we can only coax and coax the elderly. If we should persuade, we should serve three-year-old children.!

Autumn Love

[REVIEW] like autumn, because it is a gentle season.Poignant silent leaves, Cecil strands of fragrance, everything will seem net US.In such a soft season, we can talk more quietly, quietly doing things peaceful night’s sleep..  Although you can swim in the summer, but in addition, I can not find another reason to love the summer.Leaving aside the hot weather, mosquitoes just that is enough to make you worry downright.    This fall seems to come earlier than in previous years, less than in October, has been clear and crisp, Delicate thin clouds, autumn abundant Though I’ve heard Indus rain, but rain, rain, wind, cool summer has declared all had to leave, fall sections from the Tage.    Like autumn, because this is a romantic season.The other half can pull the hand, do a lot of romantic things to go for a walk the night dim alley, go Across from the night market shopping, occasional autumn, standing or Xiang Wei Jie Yan, or embracing home run.In refreshing cold day, to see similar leaves, accompanied to spring products, dependent to see the sunrise and sunset, but also in the Mid-Autumn Festival night, climb the nearby hills, watching the autumn moon hanging empty, so that “there is yin month Partly moon, people have sorrow and joy, “the poem touched the hearts.    Like autumn, because it is a gentle season.Poignant silent leaves, Cecil strands of fragrance, everything will seem net US.In such a soft season, we can more calmly talking quietly do things quietly to sleep, gently say some sweet words of love, listen to some touching love songs, so summer Zaore core cooling, return to elegant manners, attitude and thought.    Like autumn, because her pure and simple, and the pursuit of spiritual fit, nourish open the Flower of Life, gorgeous and calm.[Editor · Yee children]

Walking on the road (2014,06,05)

Hill, where sitting quietly guarding their own beliefs, no matter how clouds teasing sun, she turned a blind eye.Two magpies and take care of each other from one hill to another mountainside fly.Where there are black bars Stella trees absorb ultraviolet light with a strong dark green canopy, creating a safe and harmonious home for birds and biological needs.Magpie contracted wings drill into it, and after several more shouting noise, mountains resumed normal.    Baiyun do not know from where, and where to go, go piece by piece, the blue sky was very beautiful painting, walking on the road a few times I stepped on a roadside bushes child’s, or do not want to look from where blue sky back, it feels that situation, it was plucked from the depths of the mountains but no one found a peerless beauty, eyes wander, there may be fleeting, no longer possible to have this beauty to enjoy the same.Baiyun flower, a rose would like, for a moment such as roses, there will be a gentle greenhouse flowers, while another wild delicate pure shy.White clouds as show girls, while that image is very reminiscent of awful dance in long-sleeved, while they like to see another kind of like pushing on a Li-yan obsequiousness when the drunken beauty, while the ups and downs and if the flowers fragrant waves volume Tao buried human Love me, from where I saw a lover of beauty, she took my feeling, let me into the long infatuation with her soft bosom.    Wind blowing from the woods behind the cool wet, over the bare arms and face, like a girl’s hand can touch, can not but exciting moment of the whole body soft, very comfortable.The wind is very light very soft, but the dancing Caojian shoots of leaves and undergrowth, such as silk, although almost noon, and occasionally a few pearls scattered deep into the body, feeling very cool.From the mental state of vegetation after the morning shower, although the hot sun a few days transpiration earth has been significantly dry phase, but they are drinking enough water it floated in the air, say the root system and its surroundings also have a lot of storage ShuiBuLai.Perhaps they are in the soil and return spring also ShuiBuLai, because the ecological space they are mutually compensated.    I know that wet cool wind will soon be deprived of the sun’s burning, but perhaps this is the difference between the humidity and temperature, air flow promote a variety of floating objects, so they created a constant for environmental restoration the conditions, but also to the woods vegetation ecological role and achievements the city has excess air exchange.    Maybe my children and share ideas with the mountains, Winsor Lane residents frequently waved to me and nodded, said Trinidad and Tobago terrifying thing in the world, I am afraid of what this mountain, that many fear vegetation what I am, why I went in front of them will be so comfortable, relaxed and happy, and refreshing, and are difficult to find appropriate words to describe the children, and a lot of people and I feel the same way, why do they still afraid to As people are and describe when some thing was said, for fear of a mile.What are they afraid of it, afraid of people set fire to burn them black and blue, with a large mechanical terrifying blink of an eye, let them have no place, for fear of cement solidified their music in their homes which, for fear of shouting ecological construction, but breach of trust uprising murder create suitable living conditions for their flora and fauna?I do not know why when we think of things would say about being a mile.    Hill, just as Maitreya, potbellied accommodate Pepsi attitudes of the world, you say good or the United States can do, she still is not anyone’s likes and dislikes of the move, stuck to their creed, that all want to do our best to in the mountains create the best conditions of life, you do not really want to go against the road, she just laugh at how you dig graves for themselves.    I want to understand my hill, thought and action in good faith to repent of my past, the ignorance and ignorance will be buried at the end of the road, deep in the mountains touch the corner of my sadness sunset, the warmth of the mountain cold nearly numb heart, bring back a man of conscience, cherish and enjoy all the mountains given.

A Fed rate hike the central bank raised the shares of highs 7-day reverse repo rate

  March 22 morning, the Fed announced that the federal funds rate target range by 25 basis points to% to% level。
This is the first time since the Federal Reserve to raise interest rates this year, in line with the market had widely expected。   Affected Fed "interest rate", March 22, in the onshore RMB against the US dollar the official closing price reported, the official closing prices go over the previous day 103 points。
  A sector, the three major indices highs by the close on the 22nd, tumbled%, to close at points; Shenzhen Component Index fell percent, to close points; GEM fell percent, to close points。   The Fed chairman said the gradual rate hikes the Fed said most beneficial, improving US economic outlook as the main basis for rate hike。 At this time, the Fed believes interest rates will help moderate economic growth, the job market to maintain steady。
  The Fed released data show that US economic growth is expected this year and next to% and% respectively, compared with last December's forecast were raised percent and percentage points。 By the end of 2018, the US unemployment rate will fall to% less than in December last year predicted value per cent; by the end of 2019, the unemployment rate will be further reduced%, well below the long-term a reasonable level%。   The Fed is expected by the end of 2018, the US core inflation rate%, consistent with the December forecast。 By the end of 2019, the core inflation rate%, compared with December estimates by percentage points。
  With regard to interest rate expectations, the Fed estimates show average interest rates three times this year and next, by the end of 2020 the federal funds rate expected value% incremental rate hikes should continue to provide support to the economy。   Federal Reserve Chairman Powell believes, gradually raising interest rates will continue to support the economy, we will continue to try to avoid deviation from the inflation target, today's rate hikes raise interest rates gradually in line with the process of gradually raising interest rates next step to better achieve the Fed's objective, will constitute the economic risk is too slow to raise interest rates。   Powell said the Fed existing monetary policy framework is very effective; his personal opinion, there is no urgency to the Fed's regulatory framework; yet to decide whether to maintain the same framework in the longer term。
  CITIC Securities believes that the overall release of Powell's speech signal slightly hawkish, the market is expected to raise interest rates four times during the year to enhance。
Overall, the meeting released by a neutral signal to raise interest rates a bit more hawkish, though US Treasury yields and the dollar index down slightly, but the market interest rate four times during the year is expected to rise from the previous% to%。   The central bank raised the 7-day reverse repo bid rate by the Federal Reserve interest rate hike, the Hong Kong Monetary Authority 22 announced its benchmark interest rate by 25 basis points, from% to 2%。
  March 22 morning, People's Bank of China also carried out the appropriate action, up seven days reverse repo open market bid rate to%, up slightly over the previous five basis points%。   The central bank open market operations room official said, the open market operations interest rates up slightly in line with market expectations, the market for the Fed to raise interest rates just a normal reaction。   "The open market operations, interest rates follow the market up slightly reflecting the supply and demand of funds, further narrowing the spread between the two, it is conducive to enhancing the role of conducting open market operations interest rate on the money market interest rates, but also conducive to the formation of a reasonable market players interest rate expectations, financing constraints irrational behavior, the stability of the macro-leverage may play a role。
"Agency believes that after the Federal Reserve to raise interest rates, the level of China and the US benchmark spread narrowing。 From the point of view of interest rate parity, the presence of Chinese pressure on interest rates, interest rate levels in order to maintain stability and further stabilize international capital flows, exchange rate stability in order to achieve goals。   Jiang Chao Hai Tong Securities macroeconomic analyst believes that China is the world's second largest economy, enjoys an independent monetary policy, without having to follow the United States to adjust monetary policy。
This year the dollar continued to weaken against the dollar as a whole continues to appreciate, from the current level of appreciation to the vicinity of the yuan trend is too strong and not too weak, so no need for the central bank to raise interest rates and exchange rate stability maintenance。   Huatai Securities chief analyst Li Chao believes that China's central bank may raise interest rates again to follow。
He believes that the US interest rate with bond spreads continued to narrow, and has a 3% inflation in February the central bank to raise interest rates close to the threshold, the domestic economic performance than expected, creating space for the benchmark interest rate adjustment。   Guotai Junan that, from an economic momentum and inflation dimension, the need to raise interest rates will gradually increase, the central bank will follow the Federal Reserve is expected to raise interest rates and a slight increase modestly over the open market interest rates, will follow throughout the year to raise interest rates 3-4 times。    – Market Reaction。

"Business Week": Al build the US medical drugs Botox Botox is Born | Business Week | El build | Botox

  Botox anti-wrinkle has a magical effect of birth and manufacturing process。
Botox based on the scientific community one of the most toxic substances known botulinum manufacturing, global sales expected to reach $ 4.0 billion in 2020。
  El build Irvine, Calif Botox into the laboratory is not good, not easy to go out into the once。 But first it is to sign a disclaimer: in entering these heavily guarded laboratories 18-36 hours, visitors may have double vision, speech difficulties, limb weakness and eventually paralysis of the respiratory system。
But do not worry。   If you sign a disclaimer go inside, the beginning of the entrance is a key input password to open the door, then the door is more password。
Only a few people at work or walk。 Go inside very far behind the double windows are still more cut off, and finally came to the table with a metal enclosed。 Everything here is subject to video surveillance。
All activities record each monitor。 Security watched the coming and going from the room with a shield wall of people。   Such scrutiny and careful protection is not built El sold drugs Botox is not a competitor to steal – although Botox is worth protecting, Botox last year sales of $ 2.8 billion。
Take a variety of security measures because, for many years the young drug happens to be one of the most toxic substances known by the scientific community are made by people to get rid of wrinkles。   Botulinum toxin is extracted from botulinum toxin。 Botox thriving breeding in poorly stored canned foods。 Botox is very toxic, will be able to make a little due to respiratory muscle paralysis and suffocation, is considered one of the most deadly potential bioterrorism agents around the world, the US CDC as a possible cause of public, animal and plant health a serious threat to the height of the controlled substances。
So even if these Botox missing a little bit, Al build must explain to the United States Center for Disease Control。
When it was built to Al manufacturing facilities in Ireland, the journey reminiscent of action to defend the president's Secret Service, but less public attention。   Like so many baby aspirin dose of botulinum toxin that sufficient global supply botulinum year。
This toxin extracted from a larger source, lock somewhere in the United States, leading the list of governments and companies in a well-protected only row of people know exactly where children。
Occasionally (Al build will not say how often) some of botulinum toxin (Al built will not say how many) secretly transported to the laboratory studies Irvine。
Even more rare it is to take a private jet with botulinum toxin by a security escort to the factory in Ireland。
  Scientists need to cause massive damage to what dose of botulinum toxin disagree。 Almost no data in this regard。
But in 2001, "Journal of the American Medicine," the research article said that if one gram crystalline form of botulinum toxin uniformly dispersed and inhaled will cause more than 100 deaths。 What conditions need experts disputed the actual weaponization of Botox, Botox but the possibility of manufacturing bombs mere presence on the US government in perpetuity。 Al built thus in striking position。 The US government stepped up vigilance Al build their own secret, under the joint action of the two, almost unbreakable get Botox quasi-monopoly position。 Al Construction said botulinum neurotoxin accounted for 90% of the medical market, 75% of the US medical market。   Only the United States alone will be hundreds of botulism occur each year, a number of deaths。
Earlier this year it was in a gas station on the outskirts of Sacramento after eating bad shortbread death, the culprit is contaminated cheese sauce。   1820 years ago, a German doctor, poet Kenner (JustinusKerner) first announced what he called "sauce poisoning" an accurate description of the symptoms: drooping eyelids, accompanied by difficulty swallowing and breathing。
In the late 19th century, a team playing at the funeral musicians appear importance and muscle paralysis after eating a ham at least three deaths。
Belgium microbiology professor EmileVanErmengem discovered botox from this tragedy。
Ermengem this pathogen is considered to be named, he named according to their sausage (sausage) Latin name botulus。   The US government worried that weapons of Clostridium botulinum are not unfounded。 In urging the UN prosecutors, a large number of Al- Hussein Iraq admitted purified botulinum toxin for chemical and biological weapons warheads 25 years ago in 1991 the use of。
Earlier, the era of Nazi Germany reserve concerns Botox led coalition to develop vaccines and vaccination preparations before the Normandy landing, but the German intelligence ruled out the use of Botox weapons, so vaccination is not implemented。
Also during World War II, the United States began to study Botox own manufacturing biological weapons, this work indirectly leads to Botox。
  Botox is basically Scott (AlanScott) Monk Mainz (EdSchantz) of the invention, the use of botulinum two scientists distinct purposes。 20 1960s and 1970s, ophthalmologist Scott exploring methods of treatment in patients with strabismus, still more concerned about the military rather than medical Heights。
Mainz purified botulinum toxin is still in Mali Frederick, Maryland Chemical Corps, then went to University of Wisconsin complete purification process。
After a colleague introduced two ties still to Mainz supply of Botox Scott。
  At that time control of Botox basically does not exist。 Mainz is still the meat toxin contained in a metal tube inside, then put a metal pipe sent through the US Postal Scott。
Scott is the meat toxin into drugs, then around his own breakthrough company founded a company called Oculinum。
  The drug, also known as Oculinum, 1989 Nian approved for the treatment of strabismus and blepharospasm。 Al built first obtain permission from Scott in the hands of the drug, and then in 1991 bought directly (the following year changed its name to Clostridium botulinum)。
El build the outset treated with great caution botulinum know if misused may produce serious harm。
  Al built Botox Chief Scientific Officer Breen (MitchellBrin) almost from start to finish played a key role in the drug development process in。 1980 Bollinger Columbia University neuroscientist specializing in movement disorders。 Brin and his colleagues get Botox supply from Scott there, and Brin has been the role of medication approved by the US regulatory authorities to assess its human botulism。
Brin began on the face, chin, neck, limbs, severe muscle atrophy of patients testing Botox。
He diminished the effectiveness of botulinum toxin in awe, still like to show the former spasm patients before and after being cured of botulinum contrast Videos。 Brin's office is like a Botox museum, stood memorabilia collected over the years, including a set of Russian dolls get Botox when introduced to Russia。 Botox is the Brin's life, his California license plate number is BOTOX。
  Botulinum efficacy as follows: human muscle control by the motor nerve, motor nerve to release a chemical command muscle contraction。 Botox is hindering the release of chemical substances。
Today, Botox is approved for nine kinds of medical uses – including treatment of chronic migraine, overactive bladder and severe muscle spasms, the person being botulinum toxin to treat depression treatment trials and studies of atrial fibrillation。 US doctors use Botox is also expanding: The next area is a square jaw and neck beauty。
Herbert said, was built in the Al acquisition of Botox, Botox he believes sales of $ 10 million or。 Today, Botox sales expected in 2020 to nearly $ 4 billion。
  Al built neurotoxin never intended to become a large company。
The company was founded in the 1950s, it was a Los Angeles family run pharmaceutical company, Allergan production known as anti-allergy nasal drops。 Old co-founder Herbert (GavinHerbertSr。) Also try to develop drugs to thumb-sucking addiction without success。 A friend had recommended the development of El build the treatment of allergic conjunctivitis eye drops, so old Herbert developed the first American antihistamine eye drops。 This is the first big success was built Ayr。   Small Herbert took over the company in mid-1957, the company moved to an old theater。
Screening room is used as aseptic filling area, a balcony and a stage used as a storage area。
To the 1970s, Al has become a listed company to build a flourishing production of contact lenses and eye drops and looking to expand。
It was at that time little Herbert discovered Westport Ireland。
  Ireland's northwest coast was in deep economic trouble, Westport unemployment rate up to 30%。 A local politician to convince Westport industrial factory establish a committee aimed at attracting American companies settled。
The plant has been vacant, until the emergence of small Herbert。
It is tax relief incentives to attract small first came to Westport Herbert, when he was looking at a second site to make contact lenses。   Westport is a town of only 6,000 people, 10 years ago, the subject of a Broadway musical。
Westport who depend on agriculture and fishing, and now relies on two other resources。
One is tourism, Westport has been issued by the Irish government's coveted "fashion town" (TidyTown) title。 Another resource is Botox。   And sold drugs common situation, as Botox is completely accidental discovery。 A doctor couple, Vancouver ophthalmologist Carruthers (JeanCarruthers) and her husband, dermatologist Alastair (AlastairCarruthers) inadvertently found botulinum anti-aging properties。 Carruthers in 2012 at the TED lecture recalls that she was being treated for an eye spasm of female patient。
Once this patient did not complain of her eyebrows shot at, saying injections in that part of her beautiful。
Meanwhile Alastair looking for better treatments to eliminate frown lines。 They were investigated forehead wrinkle cooperation with botulinum toxin。
The couple receptionist to be their first patient。
As Carruthers said, a few days time the receptionist's forehead smooth and more youthful glow。 But to find someone willing to accept the facial Botox injections are not easy subjects。 So Carruthers decided to experiment on himself, and soon there is no shortage of subjects problem。
  According to research firm SSR, Botox priced at about $ 60 a usually at full price rather than discount sales。
By revenue, about 55% of the botulinum medical, and the remaining 45% for insurance does not reimburse medical cosmetic。 These people pay the full price of Botox, plus the cost of medical doctors prescribing Botox cosmetic。   Some large global pharmaceutical companies have tried to develop its own neurotoxin drugs but without success。
In 2009, spent $ 1.1 billion acquisition of development is also extracted from Clostridium botulinum experimental drug PurTox mentor。
Five years after Johnson stopped PurTox R & D。 After a potential competitor to the US Food and Drug Administration to encourage the development of botulinum biosimilar drugs。 However, there is no drug Botox and rival。
As an attempt to develop biosimilar drug Botox one of the most powerful strength of the company, Mylan company told investors in March this year, interest in this area, but not go all out。
  Botox Empire unbreakable partly because the drug is extremely complex。   Al Actavis was built in 2015 for about $ 66 billion acquisition of。
Actavis reservations Al build name, description, Botox strong brand strength。 There is a new company its own problems。
A year ago, CEO Sanders (BrentSaunders) with a friendly face an enlightened big pharmaceutical companies appear committed to limit drug prices rise。 This image of the end of October this year, when Al build a payment hold its second largest drugs to an American Indian tribe, the treatment of dry eye RESTASIS intellectual property rights。 Indian tribes in the United States enjoy sovereign immunity, a move designed to thwart Al build a form of patent litigation。
Critics fierce criticism Ayer built。 Bloomberg said Al build the practice dirty shameless and totally wrong。   Maybe Al Botox is built from somewhere in the suburbs of Irvine, departed for Westport。 Al botulinum toxin build will not disclose where or how landing ship from landing in Ireland Westport。 Al built Westport, general manager of the factory Coffey (PaulCoffey) said delivery of botulinum toxin never left El-built control, only a handful of people know the delivery status。
Botox and delivery is also very common, the middle interval may be one or more years。   Coffey said that despite the current world is all kinds of crazy behavior, but do not worry about Al build their security processes。 As to whether Sanders visited the heavily guarded Westport production area, or whether he is entitled to enter, Coffey replied "absolutely not."。   If you are trying to enter the factory Sanders Westport, several roads out of the city he wants in a corner, looking printed with the name of a construction company Al brown small logo in Westport。 This points to identify a narrow path, then a long winding road。 Botox will be shipped in along this road, through meadows and splendid gardens, passing security 24 hours on duty in a small house。 After the park is a beautiful ground shows old Herbert love of gardening。 (Old Herbert retired in mid-1995, now 85 years old, is now the owner of Newport Beach, California, a family of nursery Roger'sGardens。
) Kofi like to security than in a factory to make layers of the onion, purified botulinum toxin will be stored in the onion。
Botox storage room to install more surveillance cameras, these cameras in addition to protecting the greatest assets of Al build, but also to help engineers to remotely diagnose equipment problems。 Allowed to enter the room staff are few and must be put on civilian clothes took off his clothes before entering a full surgery。
  Botox onions from the heavily guarded center began processing into the market, Westport busy factories employ more than 800 people。
Botox is the first step in making salt water mixed with tiny purified botulinum toxin。
The mixture flows through a series of pipes into the aseptic filling room。 Temperature between filling, humidity, pressure, inert particles closely monitored indicators。
Is there a bacterial Ayer built in the sterile room to take a month to extract Jovan samples tested in air。 Even if there is a bacillus, will be investigated。
  Botulinum manufacturing process is essentially an automated process, the manufacturing apparatus installed on microscopic camera tracking。 The final step is the production of botulinum toxin injection vials salt solution, however Tempered powder。 These bottles one by one boxing, into the hands of doctors around the world。 One of the substances on the planet's most feared is now basically harmless, a very precious thing, to be injected into wrinkled brow or sweaty palms。 No more chartered by a security escort, but by delivery。 (Lemon Nan / compiler)。

Deutsche Bank: US housing market over the next few quarters will be significantly warming

US stock market center: Exclusive offer full industry sector stocks, premarket after-hours, ETF, warrants night network real-time quotes, nightlife network Finance YORK, April 22 news, recent US housing data is far from satisfactory, although the last week in April builders index has improved, but weakness in March housing starts and building permits new performance。On Wednesday, the United States will announce two real estate data: February and March data rate of existing home sales data; Thursday, US new home sales data will be released in March。  With the recent signing of second-hand housing sales data modestly higher, Deutsche Bank (Deutsche Bank) is expected in March to improve the weak home sales, estimated at 5 million, slightly higher than the 4.88 million in February。But for Thursday's new home sales data, Deutsche Bank expected to be weaker, because the housing supply in the market is very small。  Last month, the US supply of new homes available for sale was 210,000, only slightly higher than in 2012 14.40000 historic lows, well below the previous 30-year average of about 320,000。  However, the result is a shortage of supply, "Once the recovery in demand, residential construction will be accelerated," Deutsche Bank said the case report。  In fact, Deutsche Bank view, although the US housing recovery has been very slow, but the next few quarters may significantly warmer。  First, the US 30-year mortgage rates about 60 basis points lower than last year at this time, means that the purchasing power of buyers has increased the US。Deutsche Bank noted that while housing affordability slightly lower than the historical peak in January 2013 record, but still higher than at any point in the past five periods。  Second, banks continue to ease lending standards in the mortgage。Last quarter, residential real estate loans held by banks at an annual rate increase of 3.9% before January 2013 three months to achieve an annual rate of growth of 4.Best performance after a 0%。  Indeed, after 2005 years ago, the US mortgage lending standards more stringent still, at the same time for many American families, to accumulate the down payment is not an easy thing。However, Deutsche Bank believes oil prices fell last year for consumers to save about $ 100 billion in energy costs。  Deutsche Bank noted that although the savings in energy costs and other expenses but did not translate into savings up, the savings rate rose for the future of the property market would be a good。  Deutsche Bank is the final conclusion: "In summary, the US housing activity appears now conditions are ripe for a substantial rebound。"(Shofu compilation)

Venezuela condemned the US currency for oil ban

Xinhua News Agency, Caracas, March 19 (Reporters Xu Ye and Wang Ying) – 19, the Venezuelan Foreign Ministry issued a statement, strongly condemned the US President signed Trump prohibit US citizens and government entities involved in the Commission issued an encrypted digital currency currency trading oil the Executive order。
The statement said the US government's economic sanctions and financial embargo against Venezuela in violation of the UN Charter and international law, sabotage of the Venezuelan economy and people's lives。 The statement said that the government appoint release oil money is an important tool to break the dollar hegemony, to promote the domestic economy and the development of production。
Committee reiterated the government to the international community, we will unswervingly promote the development of oil and related currency block chain project, the oil money to become one of the world's most reliable digital currency encryption。
The White House announced that at 19, Trump signed an executive order prohibiting US citizens and individuals and entities within the United States or entities involved in the Venezuelan government or its agents for digital currency transactions, Executive Order came into force on 19 noon。 Executive Order says, referring to the digital currency is issued by the Venezuelan government or its agent after this year and the January 9。 The move is intended to respond to the Venezuelan government to circumvent US sanctions, issued digital currency practices。 In addition, the US Treasury Department also announced an increase in sanctions against the government appointed four current or former officials。
Sanctioned personal assets in the United States will be frozen, and Americans will be embargoed dealings。 Venezuela every year 201,712 announced the release of oil encrypted digital currency coins。
According to the Venezuelan government white paper released January 31, oil currency circulation of 100 million。 Currently oil money is in the pre-sale stage, the Commission has said that the next government will issue gold coins and other digital encryption oil money。 Since the mid-second half of 2017, the United States held in Venezuela due to the Constituent Assembly elections on the subject of the Commission to impose sanctions several times, many times to expand economic sanctions against individuals appointed current and former senior officials, also prohibits US financial institutions involved in the Venezuelan government and state-owned Petroleos de Venezuela new debt and equity transactions, prohibits US institutions involved in the transaction part of the Venezuelan public sector debt has been issued, etc.。

4 ambush venture capital bank holding over 10% regulatory storm clinging to the door of rude people

Click to view the regulatory documentation requirements, the same controller by holding a bank financial products shall not exceed 5%, the implementation of transmissive supervision of major shareholders。Future, venture capital want to be "savage" attack bank recently increased the difficulty of the door, issued a "Notice of the General Office of China Banking Regulatory Commission to do commercial bank equity management Interim Measures for the implementation of related work" and "the General Office under the China Banking Regulatory Commission on Regulating the regulators notification report matters of commercial bank shareholders' two supporting documents (hereinafter referred to as "complementary" notice "")。Documentation requirements, a single investor, the issuer or manager and the actual controller, affiliates, control persons acting in the same bank financial products hold more than 5% of the shares, set aside a year for rectification。  Comprehensive sent the last annual report and three quarterly data, the "Investor News" reporter Statistics found that in the current A shares of 26 listed banks, the stake Merchants Bank, Shanghai Pudong Development Bank, Minsheng Bank and Industrial Bank this four banks over 5% of the shareholders, the emergence of the people's insurance Group, Ampang insurance and life insurance's financial DS-rich product figure。  In this connection, the "Investor News" reporter to the parties concerned were asked to verify and, most agencies did not give a response, there are a number of banks to the Annual Report 2017 has not yet announced refused to disclose the current changes in equity。  Equity Bank to put on the "magic" January 5 this year, commercial banks in order to strengthen equity management, standardize the behavior of commercial banks shareholders, regulators make up the short board, issued a "commercial bank equity Interim Measures" (hereinafter referred to as the CBRC "approach" ), which is a clear range of shareholders, major shareholders to address the problem of abuse of shareholders' rights, the establishment of intervention operations and initiatives red line caused by market concern。  "Rules" display, the same investors and related parties, persons acting as major shareholder of the number of shares shall not be more than two commercial banks, or controlling the number of commercial banks not more than one。The main shareholder here defined as "possession or control of commercial banks more than 5% of the shares or voting rights, or the total amount of capital or total shares held less than 5%, but have a significant impact on the Management of Commercial Bank shareholders。"Subsequently, the stock of shareholders to focus on resolving regulatory issues and implement improvement, issued by the regulators complete" notification "shows that financial products can hold shares of listed commercial banks, but a single investor, the issuer or manager and the actual controller, related parties, persons acting in control of financial products total shares held by the same commercial bank shall not exceed 5% of the total shares of the commercial bank。Commercial banks not to issue major shareholders, management or other financial products through the same means of control held by commercial banks shares。  For rectification period, regulators also give a clear, supporting the "notice" requirement, in principle, should be on the date of the "measures" the implementation of the completion (ie, until January 5, 2019) within one year of corrective。  In addition, commercial banks shareholders and related parties, or persons acting alone or together hold a total stake of the total capital of commercial banks more than 1%, 5% or less, it should be through commercial banks to 10 working days after receiving the respective equity CBRC or its representative offices report。  Regulators repeatedly said in public: "In the commercial bank equity management, must implement the principle of penetration, improve the transparency of ownership, implicit norms and shareholders holding shares on behalf of the phenomenon."。CBRC in supporting the "Notice" answered reporters' questions in the next focus of consolidation, which refers to "the small and medium commercial banks and shareholders equity as key elements of corporate governance, included 2018 site inspection plan。"4 banks face rectification So, what will be the equity of commercial banks face a rectification of it?As of March 15, only Ping An Bank released the 2017 Annual Report, the latest disclosure of the ownership structure, other listed banks in 2017 three quarterly statistics point of view, China Merchants Bank, Minsheng Bank, Shanghai Pudong Development Bank and Industrial Bank are present in the same the company's products to its financial stake of more than 5% of the phenomenon, and have reached more than 10%。  Specifically, Ampang Insurance's "traditional products" held by China Merchants Bank 10.72% of the shares; Ampang Insurance's "Healthy investment portfolio", "traditional products", "traditional" were holding Minsheng Bank 6.49%, 4.4 and 56%.49% of the shares, the total stake to 15.54%; DS rich life Life's "traditional products", "capital", "universal H" respectively held by Shanghai Pudong Development Bank 9.47% 6.01% and 4.33% of the shares, a total of 19 holdings.81%, the highest proportion of bank holdings of financial products; In addition, PICC's "ordinary insurance products" and PICC Life's "a risk bonus", "universal insurance" were held by the Industrial Bank 4.56%, 3.86%, 2.28% of the shares, the total holdings of related parties 10.7%。These products are found in the top ten shareholders in the bank。  Guard against financial risks with conducting business difficult to see the proportion of equity held by banks overrun financial products all insurance funds。Why risk capital so banks prefer?South China, who asked not to be named, told the "Investor News" reporter, currently half of bank shares listed dispersed to the venture capital opportunities, many of them are party funds coveted banking license; secondly, bank stocks overall valuation is not high, getting good earnings expectations, the banking sector in 2017 rose more than 14%, has become the subject of venture capital chasing investment; moreover, bank stocks are mostly large-cap stocks, funds can be achieved placards and not that much, regarded as one of venture capital。  In fact, rumors of consolidation of venture capital holdings of banks have long。Earlier media reports said, as early as mid-2017 in the first half, Pong Group have left ICBC, China Construction Bank, Agricultural Bank of China listed the top ten shareholders。In November the same year, market rumors the regulatory requirements in Ampang Group transfers the Minsheng Bank and China Merchants Bank shares, the stake to up to 5%。To reduce the impact on the market, the regulatory authorities recommend Pong Group by way of withdrawal or non-public holdings。Currently, regulators are helping to find the right Ampang stake then set side。  In this regard, CSC analyst Yang Rong in the study reported that regulators intent on the one hand is to reduce the likelihood of financial risk of infection with the industry, on the other hand is an investment in long-term value of the bank's funding guide。  While rectification, regulators, commercial banks are also shareholders of the non-compliance of the credit limit has been restricted。Circumstances require commercial banks before the completion of the rectification, not a sequel or a new credit business, aimed at implementing the association between listed banks and shareholders to prevent transactions, transfer of benefits。  Although all parties involved are on the rectification to remain silent, but the industry still believe that this is conducive to the development bank。"Regulators will set the 5% of the placards line of financial products investment ceiling, both to prevent a similar re-staged 'Po Wan dispute' highly leveraged takeovers, but also reduces the risk of related party transactions between the bank and the shareholders of。"The analysts said。  Related reports

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